diff --git a/src/event.js b/src/event.js
index f0604503c..156bc016a 100644
--- a/src/event.js
+++ b/src/event.js
@@ -483,8 +483,9 @@ jQuery.event = {
 
 			for ( ; cur !== this; cur = cur.parentNode || this ) {
 
+				// Don't check non-elements (#13208)
 				// Don't process clicks on disabled elements (#6911, #8165, #11382, #11764)
-				if ( cur.disabled !== true || event.type !== "click" ) {
+				if ( cur.nodeType === 1 && (cur.disabled !== true || event.type !== "click") ) {
 					matches = [];
 					for ( i = 0; i < delegateCount; i++ ) {
 						handleObj = handlers[ i ];
diff --git a/test/unit/event.js b/test/unit/event.js
index 2e86eb78d..c53690abb 100644
--- a/test/unit/event.js
+++ b/test/unit/event.js
@@ -1834,6 +1834,17 @@ test( "delegated event with selector matching Object.prototype property (#13203)
 	equal( matched, 0, "Nothing matched 'toString'" );
 });
 
+test( "delegated event with intermediate DOM manipulation (#13208)", function() {
+	expect(1);
+
+	jQuery("#foo").on( "click", "[id=sap]", function() {});
+	jQuery("#sap").on( "click", "[id=anchor2]", function() {
+		document.createDocumentFragment().appendChild( this.parentNode );
+		ok( true, "Element removed" );
+	});
+	jQuery("#anchor2").trigger("click");
+});
+
 test("stopPropagation() stops directly-bound events on delegated target", function() {
 	expect(1);